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A Functional Medicine Interstitial Cystitis Protocol: Testing, Nutrition, and Supplements

445 participants: 12 mg: average 28.7% body weight loss WOMAC knee pain scores dropped by up to 75.8% More than 1 in 8 patients became completely pain-free Systolic blood pressure improved by 14.0 mmHg TRANSCEND-T2D-1 Type 2 diabetes (40 weeks) Published March 2026

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Prolonged accumulation of lipids in hepatocytes is associated with lipotoxicity, which may initiate inflammation, apoptosis and ultimately fibrosis (21)

Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14

If the clinical notes frame the treatment as improving appearance, energy, or general wellness without connecting it to a diagnosed condition, the claim fails