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The clinical significance of this faster onset remains an area of ongoing investigation

Pharmacology [edit] Pharmacodynamics [edit] Although the mechanism of action of valproate is not fully understood, [39] traditionally, its anticonvulsant effect has been attributed to the blockade of voltage-gated sodium channels and increased brain levels of the inhibitory synaptic neurotransmitter gamma-aminobutyric acid (GABA)

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