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Investigators have examined its interactions with the hypothalamic-pituitary-adrenal (HPA) axis, stress response systems, and neuroendocrine signaling, as well as its apparent ability to cross the blood-brain barrier under certain experimental conditions

Sherrer, D

The demonstration in human studies that orally administered GGC can rapidly increase cellular glutathione levels represents a dramatic leap forward in glutathione science

However, preclinical safety studies report no major toxicity across animal studies (mice, rats, rabbits, dogs) and showed no adverse effects across several organ systems