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In preliminary intervention studies, pharmacologic doses of betaine (1,500 to 6,000 mg/day) were found to reduce blood homocysteine concentrations in a small number of volunteers with normal-to-mildly elevated homocysteine concentrations (37-40)

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Vitamin B12 (cyanocobalamin) is unique it is the only one that contains the mineral cobalt

Stiles AR, Kozlitina J, Thompson BM, McDonald JG, King KS, Russell DW

C., Rokos, H., Marles, L

This specificity theoretically supports a favorable safety profile, though human data remains limited