PubChem Compound Database , CID=23327
Mitochondrial function also improves with sustained weight loss and metabolic optimization
Newer incretin-based therapies may offer additional efficacy for selected patients
The conformational change in the sensory domain is involved in the detection of the target metabolite through the genetically encoded FRET-based sensor (a tandemly fused protein)
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Concurrently, ATP synthesis is severely compromised, forcing a metabolic shift from oxidative phosphorylation to anaerobic glycolysis, resulting in lactate accumulation and intracellular acidification, further exacerbating mitochondrial injury [9]