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Receptor-specific differences include D9R7.35b and D15R299 salt bridges shared by GLP-1R and GIPR (but absent in GCGR, which has Q374 in ECL3 and I194 at position 2.67b), and GCGR-specific -stacking between Phe6 and Y138 1.36b
Richard Pratley, lead author of SUSTAIN-7, noted: "The magnitude of A1C reduction and weight loss with semaglutide exceeded that of dulaglutide at both dose comparisons" [3]
It protects your cells from damage
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