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Constipation, interestingly, shows relatively flat rates across doses, with relative risks around 4.17 to 4.41 regardless of dose level

doi: 10.1038/s43016-024-01095-7, 124 RheaE

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Nat Rev Endocrinol 14 , 390403 (2018)

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More significantly, these comprehensive analyses that generate metabolic profiles represent not only biomarkers for disease but also metabolic maps that can be used to identify specific genes responsible for disease