The second clade containing 21 members exhibited upregulation, and the third clade containing 10 members showed an initial sharp upregulation followed by downregulation
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Safety and efficacy are separate concerns
Since dulaglutide decreases monoaminergic neurotransmission in the amygdala in males but in the striatum in females (Vallof et al., 2020), the possibility that different mechanisms of action contribute to the decline in alcohol drinking in males and females should be considered