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Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics

GLP-1 has stronger effects on appetite and brain signaling, while GIP has more pronounced effects on fat tissue and glucose-dependent metabolic regulation

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Genetic instruments for GLP-1R activation were selected based on associations with traits linked to drug target effects, such as body mass index (BMI) and glycated hemoglobin (HbA1c)

DOI: 10.1126/science.1093123 Rutigliano G et al (2028): The Case for TAAR1 as a Modulator of Central Nervous System Function