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Scientific References TripleHormone-Receptor Agonist Retatrutide for Obesity (Jastreboff et al., 2023)
W., Pavkov, M
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Initially approved for treatment of Type 2 diabetes and later for obesity studies in GLP-1 are now expanding in other indications such as obstructive sleep apnea (OSA), heart failure with preserved ejection fraction (HFpEF) and chronic kidney disease (CKD)
By targeting glucagon receptors in addition to GLP-1 and GIP, it helps the body burn calories more efficiently and reduces fat storage
Deferiprone, another iron chelator, offers better oral bioavailability but still poses risks, including kidney toxicity
Understanding the available pathways helps inform decisions about whether and how to proceed
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