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It is worth noting that clinical studies and post-marketing surveillance have identified an increased risk of gallbladder-related events with GLP-1 receptor agonists, including semaglutide, though the mechanism for this association is not fully understood

The combined primary endpoint of death from cardiovascular disease, nonfatal myocardial infarction, or nonfatal stroke occurred in 569 (6.5%) of patients in the semaglutide group versus 701 (8.0%) of patients in the placebo group, yielding a significant hazard ratio of 0.8 for a 20% relative risk reduction

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