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(2) Balancing Fat Metabolism and Promoting Lipolysis and Energy Expenditure In obesity, the metabolic balance of adipose tissue is disrupted, characterized by enhanced lipogenesis and weakened lipolysis, leading to continuous fat accumulation
NNMT stands for nicotinamide N-methyltransferase
Preclinical work in obese murine models suggests that encapsulated 5-Amino-1MQ administration led to decreases in overall body weight and reductions in white adipose mass
NNMTi can block this process by precisely inhibiting NNMT, thereby reducing the formation of mature adipocytes
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