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Some patients prefer morning administration to align with their daily routine, whilst others find evening dosing more convenient
Some studies found systemic vasodilation (with likely consequent reflex tachycardia), while others failed to show this ( Most novel drugs also undergo testing for their effect on the QT interval, as QT prolongation is a marker for potential ventricular fibrillation

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For Vomiting: Stay hydrated
GMS Psycho-Social Med