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In high-fat diet-induced diabetes mice, administration of liraglutide activated pancreatic and duodenal homeobox-1 (Pdx-1), an essential regulator of proliferation and function of pancreatic -cells [56]

At the molecular level, researchers conducted a multiomics data mining study and found that multiple selenoproteins are lowly expressed in thyroid cancer (89), which is associated with reduced selenoproteins content and activity due to Se deficiency and is consistent with the results of several previous studies (90, 91).GPx3 is known to be the only member of the GPx family that can be secreted into the plasma and therefore it can play an important role in extracellular oxidative stress (92), which enhances the antioxidant defense of cells via a blockage of redox DNA destruction, thus reducing as well a reduction in the abundance of damaged cells (93)

In receptor-based analyses, the GLP-1 pathway is primarily examined in relation to the regulation of glucose-dependent insulin secretion, the inhibition of glucagon signalling, and mechanisms involved in appetite control

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In vivo data statistical analysis Statistical analyses for testing changes in the abundance of markers of peripheral inflammation or neuroinflammation were performed by constructing a linear model which was used as input for a least-squares means two-tailed t -test (described in detail below)