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doi: 10.1016/j.bbr.2015.12.030 132
In the setting of hyperglycemia, there are several sources of ROS production, such as mitochondrial superoxide production, eNOS uncoupling, and AGE-dependent NOXs activation [178,179,180]
Notably, these neurotoxic effects are rarely seen at doses below 100 mg/day in adults
In clinical studies, the increase was significant (approximately 181 micrograms per liter above baseline) but remained within physiological norms
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