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Collectively, current evidence from RCT subgroups, observational studies, and mechanistic data supports the biological plausibility and clinical relevance of complementary cardiovascular and kidney benefits with combined SGLT2i and GLP-1RA therapy (Table 2)

The most common adverse events were dose-related gastrointestinal symptoms, primarily nausea, which were previously seen with GLP-1 receptor agonists

It is foreseeable that GLP-1 weight loss drugs with superior effects and safety will become the next blockbuster

A novel oral carnitine challenge test (OCCT) was recently developed, in which the detection of Ihubacter massiliensis and/or Emergencia timonensis in the human gut can synergistically contribute to diagnosing high-TMAO producers, with 43% sensitivity and 97% specificity (95)

Game changer

And a booster taken alongside a prescription GLP-1 is redundant spending, not a risk