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non-enzymatic actions and the overall significance of DPP-4 for normal physiological regulation in humans and for the pathogenesis of metabolic disease are still largely unknown, targeting the catalytic activity has been harnessed pharmacologically, and DPP-4 inhibitors now play an important part in the therapy of T2DM

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These products are often compared by consumers to prescription GLP-1 medications, but they are not FDA-approved drugs, are not clinically equivalent to GLP-1 receptor agonists, and ingredient-level research differs significantly from finished-product trials