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These side effects are directly related to the dose and the speed of escalation
Compounded tirzepatide offers no such reliability
The extension is not a rationally designed pharmacophore, it is a residual fragment of the methionyl porcine growth hormone fusion partner used to express the protein in Escherichia coli, characterised in a companion paper in the same journal and year
The article says those trials used weekly doses in the range of 1.0 mg to 2.4 mg, and reports average weight loss of 10 to 15 percent of body weight over 68 weeks
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