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& Krebs, B

Clinical trials have found that the greatest improvement in haemoglobin A1c occurs within the first 24 weeks of treatment, after which levels stabilise

It is precisely because the effect is short and self-limiting that the pituitarys own feedback machinery remains in charge, and it is that feature, more than any other, that supporters cite when they describe secretagogues as working with rather than over the endocrine axis

But he's in his late 90s, and he's still sharp, which is incredible

That is the honest answer to the argument you will find in forum threads: the rule is conservative and administrative rather than empirical, and it is still the number to use, because the alternative is having no number at all

doi:10.1038/sj.embor.7400036