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In vitro studies have examined its interactions with keratinocytes, fibroblasts, and melanocytes, the three primary cell types of the skin

Methods Ethics declarations All the animal experiments were performed following the Guide for Care and Use of Laboratory Animals, approved by the Animal Experimentation Ethics Committee of China Pharmaceutical University (2022-10-017)

Sublingual B12 tablets are held in the mouth under the tongue, and are absorbed into the bloodstream through the mucous membranes

Primary research applications include Alzheimer's disease, vascular dementia, age-related cognitive decline, and neurological recovery after brain injury

It is indicated for the treatment of vitamin B deficiencies, neuropathies, and conditions requiring high doses of B vitamins

Vitamin B12 also plays a key role in DNA synthesis, supports cell growth and repair, and contributes to energy metabolism