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Unlike incretin agonists such as Semaglutide (GLP-1), Tirzepatide (GLP-1/GIP) or Retatrutide (GLP-1/GIP/glucagon), Cagrilintide acts via a separate pathway the amylin receptors in the central nervous system
The primary outcome measure is time to first major adverse cardiovascular event
Follow up with ongoing monitoring
PLoS One 16 (11), e0259821
The Emotional Impact There will be a lot of people who lose weight with GLP-1s who have loose skin, particularly in the face
In practice, this means starting on the lowest dose, eating smaller meals with fat spread across the day rather than concentrated in one sitting, and building up gradually
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