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Supervisory Pharmaceutical Scientist, OPQ, CDER, FDA Dr

Additional receptor destinations involve retrograde transport towards the Golgi apparatus ( Evidence from primary mouse islets and clonal beta cells (INS-1 832/3) shows that Exenatide causes a greater amount of GLP-1R degradation compared to endogenous GLP-1, with this effect apparently due to differences in the susceptibility of the agonists for degradation by the endopeptidase endothelin converting enzyme 1 (ECE1) (Metzler et al., 2001) is associated with the control of GLP-1R function

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Hsieh, P.-S., et al

If your work requires sharp cognitive function, GLP-1 medications do not carry this risk