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Finally, pro-caspase 9 has been shown to get activated by mitochondrial cytochrome c (which has been shown to be increased in ES) [204] also linking oxidative stress and mitochondrial functioning to apoptosis

These include a woman in her 20s treated at the Austin for liver injury, and a man in his 40s with major kidney injury from extreme dehydration caused by having diarrhoea about 40 times a day

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We examine when computational modelling and simulation, or CM&S, genuinely supports medical device simulation strategy and when it becomes a costly detour