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CPS1 expression is notably increased in arsenite-induced lung fibrosis and contributes to enhanced proline metabolism
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In some cases, temporary dose reduction followed by slower re-titration can allow better tolerance whilst maintaining therapeutic benefit
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[9] Important safety considerations include monitoring for signs of acute pancreatitis (severe, persistent abdominal pain, sometimes with vomiting) which requires urgent medical assessment, and potential worsening of diabetic retinopathy, particularly in patients with pre-existing retinopathy experiencing rapid improvement in blood glucose control
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