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This step is important because it provides a clear starting point

Collaboration NCDRF

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In large-scale longer-term cardiovascular outcomes trials [47, 48, 84], long-term DPP-4 inhibition was associated with no change or a small decline in glomerular function that persisted during the entire duration of follow-up (up to 4 years)

Inflammatory markers, nerve conduction studies, and metabolic parameters offer quantitative data supporting clinical assessments