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Glutathione helps inhibit the enzyme tyrosinase, which is crucial in melanin synthesis

This balance influences numerous redox-regulated cellular processes, including the modulation of signaling pathways, post-translational modifications such as protein glutathionylation, activation of transcription factors like Nrf2 and NF-B, and the regulation of cell fate decisions such as proliferation or apoptosis [38]

Glutathione and skin whitening go hand in hand

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Combining MSC-Exos with radical-trapping antioxidants or iron chelators could produce synergistic therapies, harnessing rapid radical scavenging alongside prolonged microenvironment modulation