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However, factors like UV radiation, pollution, and stress can create excess free radicals

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Approval for Diabetes and Weight Management Over the past decade, three GLP-1/GIP receptor agonists liraglutide, semaglutide, and tirzepatide initially approved by the FDA for adults with type 2 diabetes, have also gained FDA approval for chronic weight management in people without diabetes, provided they meet specific criteria: a BMI of 30, or 27 with at least one weight-related condition such as hypertension, dyslipidemia, or type 2 diabetes

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This decrease in metabolic capacity, together with changes in signaling cascades and epigenetic landscapes, leads to mitochondrial dysfunction and increased ROS production (136)

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG