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Before the switch, the most common anchor agents used alone or in combination with other anchor agents were dolutegravir (39%), darunavir (34%), and bictegravir (24%)
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Impaired activity of methionine synthase results in elevated blood concentrations of homocysteine, while impaired activity of L-methylmalonyl-CoA mutase results in increased concentrations of a metabolite of methylmalonyl-CoA called methylmalonic acid (MMA) in blood and urine