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They mimic a gut hormone

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Genome-wide identification, characterization, and expression profiling of glutathione S-transferase (GST) family in pumpkin reveals likely role in cold-stress tolerance

(PubMed) Lesser GJ, Case D, Stark N, et al

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This multifactorial assault on glutathione homeostasis creates a compelling rationale for exogenous support, particularly through delivery methods that ensure reliable tissue concentrations