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In a randomized placebo-controlled phase II trial in patients with metastatic colorectal cancer, calmangafodipir at a dose of 5 mol/kg reduced oxaliplatin-induced delay in the onset and intensity of CIPN symptoms during and after treatment and had no negative impact on progression free survival and overall survival outcomes [155]

For experiments involving alterations to the culture medium, cells were seeded in regular RPMI 1640 with 5% dialysed FBS (Gibco, 26400044) and 1% penicillin and streptomycin

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JamesSJMelnykSJerniganSClevesMAHalstedCHWongDHet al

After MCAO, the rats experienced an increase in neurological deficit scores and elevated brain water content (cerebral edema)

Some compounds may degrade faster