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For the control groups of rats, saline was injected intraperitoneally
Top 100 Drugs: Clinical pharmacology and practical prescribing
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The transfer of microbiota from obese donors to recipient mice induced the development of hyperglycemia and hyperinsulinemia, confirming the direct influence of the gut microbiome on pancreatic -cells (Martnez-Montoro et al., 2022)
Historically, the obesity pharmacotherapy literature notes early trial signals and also that development was terminated after failure to show meaningful weight loss in a larger, longer trial (as summarized in a peer-reviewed review discussing a 12-week signal and a later 24-week negative result)
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