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A note on long-term use: while most trials show Ashwagandha is safe at 300600 mg/day, recent case reports have raised questions about potential liver enzyme elevations in rare cases of prolonged high-dose use

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GLP-1 therapies are reshaping obesity, diabetes, and even cardiovascular care Demand has outpaced global manufacturing capacity A grey market has emerged and regulators are now stepping in to contain it Patients want affordable, available treatment

call NHS 111 or attend A&E Any new neck lump, difficulty swallowing, or persistent hoarseness seek prompt assessment to exclude thyroid pathology Changes in vision in people with diabetes seek prompt ophthalmic review For non-emergency concerns, NHS 111 can provide guidance on whether and how quickly to seek further care

Abbreviations ADA: American Diabetes Association CV: Cardiovascular CVOTs: Cardiovascular outcome trials GLP-1RA: Glucagon-like peptide-1 receptor agonists HR: Hazard ratios MACE: Major cardiovascular events SGLT-2i: Sodiumglucose transporter-2 inhibitors T2DM: Type 2 diabetes mellitus References Giugliano D, Maiorino MI, Longo M, Bellastella G, Chiodini P, Esposito K

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