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At the same time, the activity of GLP-1R is independently modulated by the composition of the intestinal microbiota and the content of short-chain fatty acids (SCFAs) [11]
The picture here is more nuanced than you might expect
However, research into this area is lacking, and we can't say for sure yet
--- An Important Limitation HOMA-IR is not a perfect tool
Some patients may transition off medication once they reach their target weight, while others may continue using it as part of a long-term maintenance plan
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