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Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5

JSTOR 3870806

Key Research Characteristics: Extended half-life (~2030 hours vs ~1215 minutes for native IGF-1) due to reduced IGFBP binding Potent agonist at IGF-1R, studied for roles in cellular proliferation, differentiation, and survival signalling Investigated in models of muscle hypertrophy, neuroprotection, and metabolic regulation 83 amino acid analogue

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