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doi: 10.1038/s41581-020-0256-y 12 YuanJOfengeimD
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This creates a compounding effect where both the medications direct effects AND the weight loss contribute to reduced tolerance
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The maximum recommended dose varies based on the specific indication and individual patient factors, but generally does not exceed 2.5 mg weekly for most patients
The synergy of GIPR and GLP-1R signaling within the pancreas, adipose tissue, central nervous system, and potentially the liver provides a robust framework for how tirzepatide could help reduce the progression or outcome of MASLD
