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doi:10.1016/j.anl.2021.03.006

GHK-Cu stimulates angiogenesis primarily through upregulation of key growth factors including vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF/FGF-2), with research demonstrating that GHK-Cu at nanomolar concentrations increases VEGF expression in dermal fibroblasts and stimulates human umbilical vein endothelial cell (HUVEC) proliferation through enhanced VEGF and FGF-2 expression

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Both peptides are actively researched for their purported abilities to promote healing in various tissues and organs