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Elevated values may indicate inflammation or fluid imbalance factors that affect metabolic signalling
Abstract Astrocyte senescence has been identified as a factor in the progression of Parkinsons disease (PD) and the onset of age-related cognitive decline
Signaling pathways documented in literature: Telomerase activation (hTERT): Cellular models document induction of telomerase activity and telomere elongation in cultured human fibroblasts Circadian modulation: Preclinical rodent studies describe normalization of melatonin secretion and circadian rhythm Gene Regulation / Chromatin Experimental literature reports effects on gene expression and chromatin structure (perinuclear heterochromatin)
Additionally, apigenin exhibits antioxidant activity by increasing superoxide dismutase (SOD), glutathione peroxidase (GPx), and reduced malondialdehyde (MDA) levels in the injured brain (T
PMCID: PMC8789089 Pickart L, Vasquez-Soltero JM, Margolina A
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