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Currently, a clinical trial of E6011 (an anti-CX3CL1 mAb) has been demonstrated to have a promising role in active RA patients ( ( Figure 2 )

The vitamin B12 deficiency involved in pernicious anemia is not brought on by inadequate diet, but rather by a relatively rare condition that inhibits the absorption of vitamin B12 in the gut, per MedlinePlus Medical Encyclopedia

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B12 deficiency symptoms include (2, 3): Megaloblastic anemia Fatigue and weakness Constipation Loss of appetite and weight loss