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GLP-1 RAs may also improve liver function, this effect is thought to involve activation of AMP-activated protein kinase (AMPK), a key metabolic regulator that inhibits fatty acid synthesis and promotes fatty acid -oxidation, leading to decreased lipid accumulation in hepatocytes 22,23,24,25

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Based on these results, we concluded the binding mode between COP1 and c-Jun is similar to that of Trib1

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