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The individual study effect sizes were then entered into a random effects meta-analytic model using restricted maximum likelihood estimation

Yeoh E, Choudhary P, Nwokolo M, Ayis S, Amiel SA (2015) Interventions that restore awareness of hypoglycemia in adults with type 1 diabetes: a systematic review and meta-analysis

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They may be cautious about escalating the dose if your A1c is already well controlled, even if your weight has plateaued

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Growing Demand The growing demand for GLP-1 medications continues to place pressure on insurance carriers, employers, and government programs attempting to balance patient access with rising pharmaceutical expenditures