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HIF activation reprograms cellular metabolism by upregulating glycolytic gene expression in inhibiting pyruvate entry into the TCA cycle [53], thereby mediating a shift from oxidative phosphorylation to glycolysis

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The optical density was detected at 410 nm using SpectraMax M5

Excessive Sun Exposure UV radiation stimulates melanin production and triggers oxidative stress, which directly opposes the skin brightening effects of glutathione