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GLP-1 (pptido similar al glucagn tipo 1) y GIP (polipptido insulinotrpico dependiente de glucosa) son hormonas naturales del tracto gastrointestinal conocidas como incretinas, fundamentales en la regulacin del azcar en sangre y el metabolismo energtico
This is exemplified by experimental models showing that selective ablation or stimulation of Agouti-related peptide (AgRP)/NPY/GABA neurons in the basomedial hypothalamus leads to either starvation or hyperphagia with subsequent obesity, respectively (114, 115)
approval unlikely before 2027
Furthermore, it has been reported that the administration of exenatide attenuates the renal inflammation index, including reducing the TNF-, IL-6, hsCRP, and CCL5 levels, in STZ-induced diabetic rats by increasing the superoxide dismutase and decreasing malondialdehyde levels (Wang et al., 2019)
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