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It is therefore unsurprising that the LD 50 values for compounds 1 and 2 determined ex vivo have a similar discordance to that seen for PZQ when considering in vivo PK/PD: much like PZQ these compounds are schistosomicidal in vivo at sub LD 50 concentrations
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This is an easy way to correct it
candidate agents such as lycopene and melatonin have been confirmed to simultaneously alleviate inflammatory injury and oxidative stress responses in animal models via signaling networks like NF-B/MAPK and Nrf2 (210, 211)
It means the evidence is not yet strong enough to make definitive claims
It has been shown to skew the production away from the darker eumelanin and toward the lighter pheomelanin
