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This HO-CO pathway has been recently proposed to be involved in the defence against oxidative stress and the deleterious effects of NO, since it removes the cytotoxic free heme, and produces some molecules with antioxidant and anti-inflammatory effects, such as biliverdin and CO [8, 3840]
doi: 10.1073/pnas.0704329104 318 FarahCMichelLYMBalligandJL
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It acts as a primary protector against oxidative stress and helps maintain our internal balance
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