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longer courses generally mean slower or incomplete return of semen parameters

In the first year following diagnosis, we found increased cumulative incidence risk ratios in a number of outcomes including: - Any mental, behavioural, or neurodevelopmental disorder 1.96 (1.93 - 1.99) - Postpartum depression 2.70 (2.61 - 2.79) - Eating disorders 2.06 (1.85 - 2.89) - PTSD 1.77 (1.69 - 1.86) We also saw significantly increased risk in rare but serious outcomes such as: - Wernicke's encephalopathy 2.39 (1.25 - 4.56) - Puerperal psychosis 1.80 (1.48 - 2.20) Interestingly, cases of hyperemesis gravidarum with metabolic disturbance displayed a significantly lower risk of any depression and postpartum depression compared with those without metabolic disturbance

doi: 10.3390/nu13030762 38 CalabriaACGallagherPRSimmonsRBlinmanTDe LeonDD

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Science 334 , 252255 (2011)

It has been linked to reductions in oxidative stress, protection of mitochondrial DNA, and modulation of gene expression related to energy balance