GLP-1 originating from the gut has a very short circulating half-life of only 12 min due to its rapid inactivation by the enzyme dipeptidylpeptidase-4 (DPP-4) and subsequent clearance through the kidneys
While we are still learning more about the relationship between diet and GLP-1 production, most of these principles result in a healthier diet overall regardless of GLP-1 production
Moreover, amygdala responses are attenuated following the consumption of high-fat foods, reducing subsequent responses to further food stimuli (131)
Mondino Foundation, National Neurological Institute, University of Rome La Sapienza, Dipartimento di Neuroscienze Umane
DURATION-5: exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes
Regarding hepatic effects, GLP-1 receptors are expressed at low levels in hepatocytes, though their functional significance remains debated