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The weight loss produced by GLP-1 medications is genuine and clinically significant trials of semaglutide (Wegovy) have shown average weight loss of 15 to 20% of body weight over 68 weeks, which is comparable to the outcomes of bariatric surgery for many patients
In May 2024, KFF similarly reported ~12% had ever used one
Exendin-4, the GLP-1 analogue, is better studied, with an estimated half-life of 18-41 minutes for IV administration in rat models (see reference 6)
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Additionally, the study reported lower all-cause mortality among GLP-1 users, which, while encouraging, complicates interpretation of the dementia findings patients who live longer may simply have more time to develop cognitive symptoms
This article explores the benefits of morning versus evening dosing, how timing affects potential side effects, and why consistency is the most important factor for your success
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