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Abbreviations TNBC: Triple-negative breast cancer BC: Breast cancer ER: Estrogen receptor PR: Progesterone receptor HER2: Human epidermal growth factor receptor 2 ACD: Accidental cell death PCD: Programmed cell death LCD: Lysosome-dependent cell death PAMPs: Pathogen-associated molecular patterns DAMPs: Damage-associated molecular patterns TNF: Tumor necrosis factor FasL: Fas ligand TRAIL: TNF-related apoptosis inducing ligand FasRs: Fas receptors TNFR1: Tumor necrosis factor receptor 1 DR4: Death receptor 4 DR5: Death receptor 5 DISC: Death-inducing signal complex ROS: Reactive oxygen species Cytc: Cytochrome C ATR: ATM and rad3-related CCL2: CC motif chemokine ligand 2 EMT: Epithelial mesenchymal transition CSC: Cancer stem cell CTL: Cytotoxic T-lymphocyte NLRP3: NOD-like receptor thermal protein domain associated protein 3 AIM2: Absent in melanoma 2 ASC: Apoptosis-associated speck-like protein containing a CARD PYD: Pyrin domain HIN200: Hematopoietic interferon-inducible nuclear 200 proteins CARD: Caspase recruitment domain LPS: Lipopolysaccharides DC: Dendritic cell RIPK: Receptor interacting protein kinase MLKL: Mixed lineage kinase domain-like HMGB1: High mobility group box-1 protein ATGs: Autophagy-related genes mTORC1: Mechanistic target of rapamycin complex 1 PI3K: Phosphatidylinositol 3 kinase LC3: Microtubule associated protein light chain 3 PE: Phosphatidylethanolamine STX17: Syntaxin-17 SNAP29: Synaptosome associated protein 29 VAMP8: Vesical-associated membrane protein 8 TFR1: Transferrin receptor FPN1: Ferroportin 1 LIP: Labile iron pool GPX4: Glutathione peroxidase 4 GSH: Glutathione IRP: Iron regulatory protein Nrf2: Nuclear factor erythroid 2-related factor 2 FADD: Fas-associated protein with death domain ZDHHC1: Zinc finger DHHC-type containing 1 AML: Acute myeloid leukemia HSPA5: Heat shock protein family A member 5 LSD1: Lysine-specific demethylase 1 TRAF6: TNF receptor-associated factor 6 MDR: Multiple drug resistance AC: Anomanolide C TIM-3: T cell immunoglobulin and mucin domain-containing protein 3 TAMs: Tumor-associated macrophages CAR-T: Chimeric antigen receptor T cell immunotherapy TCR-T: Receptor-engineered T cell MDSCs: Myeloid-derived suppressor cells VDAC: Voltage-dependent anion channel MAPK: Mitogen-activated protein kinase ERK: Extracellular regulated protein kinases JNK: C-Jun n-terminal kinase IAPs: Inhibitor of apoptosis proteins -GCS: -Glutamylcysteine synthetase RSL3: RAS-selective lethal 3 References Leon-Ferre RA, Goetz MP

Fras JP, et al