Oral GLP-1s for obesity saw a recent setback when in April (April 2025), Pfizer announced that it was discontinuing development of danuglipron, an oral GLP-1 receptor agonist, which was being investigated for chronic weight management, due to potential liver toxicity
Rapid injection forces medication into the tissue faster than it can accommodate, creating a pressurized pocket that causes pain and can push medication back out through the needle track
The safety and effectiveness of Vyvanse for the treatment of obesity have not been established. Risks of Vyvanse for weight loss As Alex Foxman, MD, internist and medical director of Achieve Health and Weight Loss, emphasizes, Vyvanse is not a safe or effective way to lose weight outside of healthcare provider-guided binge eating disorder treatment
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A consultation with a provider to determine candidacy is recommended