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At the heart of the FDAs concern is the chemical composition of the drug itself

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Potaczek, Philipps-University of Marburg, Germany Reviewed by Jiajun Yang, China Agricultural University, China Edward Brell, Australian Self Medication Industry Inc, Australia Lucia Giannini, University of Milan, Italy Updates Copyright 2026 El-Saadony, Saad, Sitohy, Alkafaas, Dladla, Ghosh, Mohammed, Ibrahim, Fahmy, Elkelish, AbuQamar and El-Tarabily

While no single direct mechanism has been definitively established, fatigue likely results from multiple factors including substantial caloric restriction, gastrointestinal side effects, dehydration, and metabolic adaptation during weight loss

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